Current challenges in laboratory diagnostics of autonomous cortisol secretion in adrenal incidentalomas

Adrenal incidentalomas are unexpectedly identified adrenal masses without prior suspicion of the existence disease. The majority benign adenomas (80-90%), and they non-functioning adrenocortical in more than 70% cases. Mild hypercortisolemia is most common finding hormonally active incidentalomas. It defined as autonomous cortisol secretion up to 15% patients. Despite a lot research that anticipated higher cardiometabolic risk patients with secretion, there still no clear consensus on biochemical criteria for an diagnosis This review delineates advantages limitations different laboratory tests recommended